Increased rates of meal absorption do not explain elevated 1-hour glucose in subjects with normal glucose tolerance

Jon D. Adams, Gerlies Treiber, Maria Daniela Hurtado, Marcello C. Laurenti, Chiara Dalla Man, Claudio Cobelli, Robert A. Rizza, Adrian Vella

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Context: In subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), glucose concentrations .155 mg/dL 1 hour after 75 g of oral glucose predict increased risk of progression to diabetes. Recently, it has been suggested that the mechanism underlying this abnormality is increased gut absorption of glucose. Objective: We sought to determine the rate of systemic appearance of meal-derived glucose in subjects classified by their 1-hour glucose after a 75-g oral glucose challenge. Design: This was a cross-sectional study. Participating subjects underwent a 75-g oral glucose challenge and a labeled mixed meal test. Setting: An inpatient clinical research unit at an academic medical center. Participants: Thirty-six subjects with NFG/NGT participated in this study. Interventions: Subjects underwent an oral glucose tolerance test. Subsequently, they underwent a labeled mixed meal to measure fasting and postprandial glucose metabolism. Main Outcome Measures: We examined βcell function and the rate of meal appearance (Meal Ra) in NFG/NGT subjects. Subsequently, we examined the relationship of peak postchallenge glucose with Meal Ra and indices of βcell function. Results: Peak glucose concentrations correlated inversely with βcell function. No relationship of Meal Ra with peak postchallenge glucose concentrations was observed. Conclusion: In subjects with NFG/NGT, elevated 1-hour peak postchallenge glucose concentrations reflect impaired βcell function rather than increased systemic meal appearance.

Original languageEnglish (US)
Pages (from-to)135-145
Number of pages11
JournalJournal of the Endocrine Society
Issue number1
StatePublished - 2019


  • 60-min glucose
  • disposition index
  • splanchnic glucose uptake

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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