Abstract
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 263-268 |
| Number of pages | 6 |
| Journal | Radiology |
| Volume | 204 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1997 |
Keywords
- Gadolinium
- Magnetic resonance (MR), guidance
- Ultrasound (US), focused
- Ultrasound (US), technology, Ultrasound (US), therapeutic
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Fingerprint
Dive into the research topics of 'In vivo target-specific delivery of macromolecular agents with MR- guided focused ultrasound'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS