In vitro studies of insulin-like growth factor I and bone

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45 Scopus citations


Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish (US)
Pages (from-to)S107-S110
JournalGrowth Hormone and IGF Research
Issue numberSUPPL. B
StatePublished - 2000


  • IGFBP protease
  • IGFBP-4 and -5
  • Insulin-like growth factor I
  • Insulin-like growth factor-binding protein (IGFBP)
  • Osteoblast

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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