Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma

Paul D. Brown, Jan C. Buckner, Judith R. O'Fallon, Nancy L. Iturria, Brian P. O'Neill, Cerise A. Brown, Bernd W. Scheithauer, Robert P. Dinapoli, Robert M. Arusell, Walter J. Curran, Ross Abrams, Edward G. Shaw

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Purpose The outcome and cognitive performance data collected in a prospective, intergroup clinical trial were analyzed to assess the prognostic importance of the baseline (before radiotherapy) Mini-Mental State Examination (MMSE) score in patients with low-grade glioma. Methods and materials The patients studied were 203 adults with a supratentorial low-grade glioma randomly assigned to low-dose (50.4 Gy in 28 fractions) or high-dose (64.8 Gy in 36 fractions) localized radiotherapy. Folstein MMSE scores and neurologic function scores at baseline in combination with multiple other baseline variables were analyzed. The median follow-up was 7.4 years for the 101 patients still alive. Results Patients (n = 36) with an abnormal baseline MMSE score (≤26) had a worse 5-year progression-free survival rate (27% vs. 60%; p <0.001) and overall survival rate (31% vs. 76%; p <0.001) compared with those with a normal score. On multivariate analysis, the baseline MMSE score was a statistically significant predictor of survival. Other factors associated with overall survival were age, tumor size, and tumor histologic type. Conclusion The presence of an abnormal baseline MMSE score was a strong predictor of poorer progression-free and overall survival for patients with a low-grade glioma. The baseline MMSE should be considered in future prognostic scoring systems.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number1
StatePublished - May 1 2004


  • Glioma
  • Mini-Mental State Examination
  • Multivariate analysis
  • Prognosis
  • Radiotherapy

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


Dive into the research topics of 'Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma'. Together they form a unique fingerprint.

Cite this