Impedance of Novel Therapeutic Technologies: The Case of Stem Cells

David G. Zacharias, Timothy J. Nelson, Paul S. Mueller, C. Christopher Hook

Research output: Contribution to journalArticlepeer-review


Embryonic stem cell (ES) technology has advanced considerably within the past three decades and has gained prominent distinction within the emerging field of regenerative medicine. As it now enters the nascent stages of clinical application, many hopes and expectations arise along with questions as to where the technology will go. This paper evaluates the technical and practical obstacles that must be overcome before it can fully translate into the clinical context, the existence of strong opposition to the technology, political and legal barriers that have impeded its progression, and the role of healthcare reform in creating new social and economic priorities. In contrast to the technological imperative, a driving force seeking to implement the most recent scientific advances into medical practice, we refer to such translational obstacles as "technological impedance." Rather than expending inordinate effort to preserve existing systems that continue to possess major hurdles, we advocate fostering interdisciplinary approaches in the development of new generation platforms and embracing disruptive innovations that create solutions to technological impedance and move us forward in healthcare delivery.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalClinical and translational science
Issue number5
StatePublished - Oct 2012


  • Biomedical ethics
  • Human embryonic stem cells
  • Induced pluripotent stem cells
  • Regenerative medicine

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience


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