Impact of prior nicotine replacement therapy on smoking cessation efficacy

Michael J. Durcan, Jonathan White, Douglas E. Jorenby, Michael C. Fiore, Stephen I. Rennard, Scott J. Leischow, Mitchell A. Nides, John A. Ascher, J. Andrew Johnston

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Objective: To examine previous use of nicotine replacement therapy (NRT) on the smoking-cessation efficacy of bupropion sustained release (SR). Methods: Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study. Smokers who had, based on self-report, no previous history of NRT (N=453) or who had used NRT at least once (N=440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS. Results: Bupropion SR showed similar efficacy in participants with or without previous use of NRT. Conclusion: Bupropion SR is effective in promoting smoking abstinence regardless of prior NRT use.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalAmerican Journal of Health Behavior
Issue number3
StatePublished - 2002

ASJC Scopus subject areas

  • Health(social science)
  • Social Psychology
  • Public Health, Environmental and Occupational Health


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