Impact of hypoalbuminemia on the prognosis of relapsed/refractory B-cell lymphoma treated with axicabtagene ciloleucel

Megan Melody, Sangeetha Gandhi, Zaid Abdel Rahman, Paula Lengerke-Diaz, Nicole Gannon, Allison Rosenthal, Tuan Truong, Mattia Novo, Eva Brandes, Gina Lange, Breana Estby, Patrick Johnston, Steve Ansell, N. Nora Bennani, Jonas Paludo, Jose Villasboas Bisneto, Ernesto Ayala, Han W. Tun, Hemant S. Murthy, Vivek RoyJames Foran, Januario Castro, Yi Lin, Mohamed A. Kharfan-Dabaja

Research output: Contribution to journalArticlepeer-review


Introduction: Hypoalbuminemia is a known adverse prognostic factor in lymphomas. Yet, it is unknown if axicabtagene ciloleucel (axi-cel) overcomes the adverse prognostic impact of hypoalbuminemia in relapsed/refractory large B-cell lymphoma. Methods: We conducted a retrospective analysis across three Mayo Clinic centers to assess the relationship of hypoalbuminemia (defined as a serum albumin (SA) levels ≤ 3.5 g/dL) on outcomes of patients treated with axi-cel. Results: This analysis included 81 patients. Two patients had no available SA levels preceding axi-cel infusion. Eighteen patients (22.8%) had hypoalbuminemia with a median SA of 3.3 g/dL. Patients with normal SA had a statistically higher ORR than those without hypoalbuminemia (P =.018). There was no difference in 1-year PFS and OS between the group with hypoalbuminemia and the group with normal SA levels (48% vs 49%, P =.81) and (74% vs 73%, P =.97), respectively. There was no difference in the severity or median duration of cytokine release syndrome or neurotoxicity between the two groups. Conclusion: Notwithstanding the limitations related to the relatively small sample size, axi-cel therapy appears to overcome the adverse effect of hypoalbuminemia on OS and PFS. Large multicenter clinical studies are certainly needed to validate these findings.

Original languageEnglish (US)
Pages (from-to)48-53
Number of pages6
JournalEuropean Journal of Haematology
Issue number1
StatePublished - Jul 2021


  • chimeric antigen receptor T cell
  • cytokine release syndrome
  • diffuse large B-cell lymphoma
  • neurotoxicity
  • serum albumin

ASJC Scopus subject areas

  • Hematology


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