@article{fbccf1fe45ec473b87d32f80ea4f3010,
title = "Impact of early life exposure to ionizing radiation on influenza vaccine response in an elderly Japanese cohort",
abstract = "The objective of this study was to evaluate effects of whole body radiation exposure early in life on influenza vaccination immune responses much later in life. A total of 292 volunteers recruited from the cohort members of ongoing Adult Health Study (AHS) of Japanese atomic bomb (A-bomb) survivors completed this observational study spanning two influenza seasons (2011–2012 and 2012–2013). Peripheral blood samples were collected prior to and three weeks after vaccination. Serum hemagglutination inhibition (HAI) antibody titers were measured as well as concentrations of 25 cytokines and chemokines in culture supernatant from peripheral blood mononuclear cells, with and without in vitro stimulation with influenza vaccine. We found that influenza vaccination modestly enhanced serum HAI titers in this unique cohort of elderly subjects, with seroprotection ranging from 18 to 48% for specific antigen/season combinations. Twelve percent of subjects were seroprotected against all three vaccine antigens post-vaccination. Males were generally more likely to be seroprotected for one or more antigens post-vaccination, with no differences in vaccine responses based on age at vaccination or radiation exposure in early life. These results show that early life exposure to ionizing radiation does not prevent responses of elderly A-bomb survivors to seasonal influenza vaccine.",
keywords = "Antibodies, Atomic-bomb radiation, Chemokine, Cytokine, Influenza vaccine, Radiation",
author = "Tomonori Hayashi and Lynch, {Heather E.} and Susan Geyer and Kengo Yoshida and Keiko Furudoi and Keiko Sasaki and Yukari Morishita and Hiroko Nagamura and Mayumi Maki and Yiqun Hu and Ikue Hayashi and Seishi Kyoizumi and Yoichiro Kusunoki and Waka Ohishi and Saeko Fujiwara and Munechika Misumi and Ivo Shterev and Janko Nikolich-{\v Z}ugich and Donna Murasko and Hale, {Laura P.} and Sempowski, {Gregory D.} and Kei Nakachi",
note = "Funding Information: The Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan, is a private, non-profit foundation funded by the Japanese Ministry of Health, Labor and Welfare and the United States of America Department of Energy (US-DOE), the latter in part through DOE Award DE-HS0000031 to the US National Academy of Sciences. This study was based on RERF Research Protocol RP#3-09 and was supported by the US National Institutes of Health (NIAID Contract HHSN272200900059C). Research at Duke University was performed in the Duke Regional Biocontainment Laboratory which received partial support for construction from the US National Institutes of Health (NIAID; UC6-AI058607). The views of the authors do not necessarily reflect those of the two governments. Funding Information: The Radiation Effects Research Foundation (RERF), Hiroshima and Nagasaki, Japan, is a private, non-profit foundation funded by the Japanese Ministry of Health, Labor and Welfare and the United States of America Department of Energy (US-DOE), the latter in part through DOE Award DE-HS0000031 to the US National Academy of Sciences. This study was based on RERF Research Protocol RP#3-09 and was supported by the US National Institutes of Health (NIAID Contract HHSN272200900059C ). Research at Duke University was performed in the Duke Regional Biocontainment Laboratory which received partial support for construction from the US National Institutes of Health (NIAID; UC6-AI058607 ). The views of the authors do not necessarily reflect those of the two governments. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = oct,
day = "29",
doi = "10.1016/j.vaccine.2018.09.054",
language = "English (US)",
volume = "36",
pages = "6650--6659",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "45",
}