Immunotransplant: Preventing unintended consequences

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


T-cell transfer into lymphodepleted recipients results not only in homeostatic activation of the infused cells but also in T-cell inhibition due to upregulation of immune checkpoint receptors including PD-1 and CTLA4, thereby mitigating T-cell efficacy. Dual checkpoint blockade of PD-1 and CTLA4 in conjunction with lymphodepletion—an “immunotransplant”—uncouples the T-cell inhibition from activation and amplifies the T-cell antitumor immune response.

Original languageEnglish (US)
Pages (from-to)1487-1489
Number of pages3
JournalCancer discovery
Issue number11
StatePublished - Nov 2019

ASJC Scopus subject areas

  • Oncology


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