Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families

V. Taneja, N. K. Mehra, R. R. Singh, C. Anand, A. N. Malaviya

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalJournal of Rheumatology
Issue number2
StatePublished - 1993


  • HLA haplotypes
  • immunogenetics
  • multicase families
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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