Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families

V. Taneja; N. K. Mehra; R. R. Singh; C. Anand; A. N. Malaviya

Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families

V. Taneja, N. K. Mehra, R. R. Singh, C. Anand, A. N. Malaviya

Immunology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ² = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

Original language	English (US)
Pages (from-to)	253-258
Number of pages	6
Journal	Journal of Rheumatology
Volume	20
Issue number	2
State	Published - 1993

Keywords

HLA haplotypes
immunogenetics
multicase families
rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families",

abstract = "HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.",

keywords = "HLA haplotypes, immunogenetics, multicase families, rheumatoid arthritis",

author = "V. Taneja and Mehra, {N. K.} and Singh, {R. R.} and C. Anand and Malaviya, {A. N.}",

year = "1993",

language = "English (US)",

volume = "20",

pages = "253--258",

journal = "Journal of Rheumatology",

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TY - JOUR

T1 - Immunogenetics of familial rheumatoid arthritis

T2 - A study of 41 multicase families

AU - Taneja, V.

AU - Mehra, N. K.

AU - Singh, R. R.

AU - Anand, C.

AU - Malaviya, A. N.

PY - 1993

Y1 - 1993

N2 - HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

AB - HLA haplotypes were studied in 41 unrelated families from North India with multiple cases of rheumatoid arthritis. Affected sibpairs shared parental HLA haplotypes more often than expected (χ2 = 13.6) according to Mendelian segregation. Using the method of sibpair ratio, nonrandom segregation of parental haplotypes was observed among affected sibs. HLA-DR4 was observed in 70% of the probands while among DR4 negative probands, DR10 occurred more frequently. However no specific haplotypic association with the disease was observed in these families.

KW - HLA haplotypes

KW - immunogenetics

KW - multicase families

KW - rheumatoid arthritis

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M3 - Article

C2 - 8474060

AN - SCOPUS:0027446855

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VL - 20

SP - 253

EP - 258

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 2

ER -

Immunogenetics of familial rheumatoid arthritis: A study of 41 multicase families

Abstract

Keywords

ASJC Scopus subject areas

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