IL-4 biology: Impact on normal and leukemic CLL B cells

Neil E. Kay, Brian T. Pittner

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


This review provides a perspective on the role of IL-4 in relation to both normal and leukemic CLL B cells. IL-4 is a well-characterized cytokine known to be produced by normal T cells and have impact on normal B cell differentiation and proliferation. This cytokine and its receptor are now known to exist on CLL B cells. An autocrine pathway for CLL B cells is strongly supported by signaling events, alteration of apoptotic proteins and changes in apoptosis resistance. Based on the increasing knowledge regarding the IL-4 pathway unique opportunities for therapy are now available in B-CLL.

Original languageEnglish (US)
Pages (from-to)897-903
Number of pages7
JournalLeukemia and Lymphoma
Issue number6
StatePublished - Jun 1 2003


  • Apoptosis
  • B-CLL
  • IL-4
  • IL-4R

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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