Idiopathic autonomic neuropathy: Clinical, neurophysiologic, and follow-up studies on 27 patients

Guillermo A. Suarez, Robert D. Fealey, Michael Camilleri, Phillip A. Low

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


We evaluated the natural history, electrophysiologic characteristics, spectrum of autonomic involvement, pathology, and laboratory features in 27 patients with idiopathic autonomic neuropathy who were followed up for a mean of 32 months. The typical features of idiopathic autonomic neuropathy include the absence of an associated disease, frequent history of preceding infection, and acute or subacute onset with a monophasic course. The spectrum of autonomic involvement ranges from panautonomic to selective adrenergic or cholinergic failure. There is infrequent involvement of somatic nerve fibers as assessed by routine nerve conduction studies. Pathologic features include the presence of a small inflammatory mononuclear cell infiltrate in the epineurium. Recovery tends to be gradual and frequently incomplete. The acute onset, frequent antecedent viral infection, selectivity of involvement by fiber type and autonomic level, and presence of perivascular mononuclear cell infiltration suggest that the underlying mechanism is likely to be immune-mediated. These observations may justify plasma exchange or other immunosuppressive modalities as early therapeutic intervention in patients with progressive disability.

Original languageEnglish (US)
Pages (from-to)1675-1682
Number of pages8
Issue number9
StatePublished - Sep 1994

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Idiopathic autonomic neuropathy: Clinical, neurophysiologic, and follow-up studies on 27 patients'. Together they form a unique fingerprint.

Cite this