Identification of t(1;19)(q12;p13) and ploidy changes in an ependymosarcoma: A cytogenetic evaluation

Abeer Z. Tabbarah, Austin W. Carlson, Angelica Oviedo, Rhett P. Ketterling, Fausto J. Rodriguez

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Gliosarcoma, a recognized subtype of glioblastoma, is a biphasic tumor exhibiting distinct glial and sarcomatous components. Ependymosarcomas are rarer, biphasic ependymal tumors exhibiting sarcomatous change. Genetic abnormalities associated with this curious phenotype are not well understood. We are presenting the first karyotype of ependymosarcoma with identification of a clonal t(1;19)(q12;p13). Fluorescence in situ hybridization (FISH) was performed with a probe set targeting 1q23 and 19p13.3. Although the tumor did not show evidence of t(1;19)(q23;p13.3) by FISH, increased ploidy was a feature of the sarcomatous component. On clinical followup the patient is doing well without evidence of recurrence 55 months after initial resection, and postoperative treatment with irradiation and temozolomide. The significance of the genetic alterations we describe associated with sarcomatoid change in ependymal neoplasms, and ultimately their prognostic relevance, merits further study.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalClinical Neuropathology
Issue number3
StatePublished - May 2012


  • Cytogenetics
  • Ependymoma
  • Ependymosarcoma
  • FISH
  • Gliosarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology


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