Hypothermia inhibits cell proliferation and nitric oxide synthase expression in rats

Kwang Sik Lee, Baek Vin Lim, Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Young Pyo Kim, Ho Su Shin, Seong Yeon Cho, Hong Kim, Mal Soon Shin, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


In the present study, the effects of cold-water immersion on cell proliferation and nitric oxide synthase expression in the dentate gyrus of rats were investigated. Sprague-Dawley rats were divided into four groups: the control-rest group; the control-heat group; the cold-rest group; and the cold-heat group. Cold-water immersion for 5 min at 4°C suppressed the numbers of 5-bromo-2′-deoxyuridine-positive and nicotinamide adenine dinucleotide phosphate-diaphorase-positive cells in the dentate gyrus, and these numbers were increased by warming for 30 min at 30°C. In the present study, it was demonstrated that warming protects against cold stress-induced suppression of new cell formation, and results suggest that nitric oxide, the synthesis of which is affected adversely by cold-water immersion, may play an important role in the regulation of cell proliferation.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - Aug 23 2002


  • Cell proliferation
  • Cold-water immersion
  • Dentate gyrus
  • Nitric oxide synthase

ASJC Scopus subject areas

  • General Neuroscience


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