Hypothalamic hamartoma with neurofibrillary tangles

Seiji Yamada, Christopher P. Wood, Jawad A. Shah, Jonathan Vida, Joseph E. Parisi, Mark E. Jentoft

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Hypothalamic hamartomas are rare tumors that typically present in childhood, often with gelastic seizures, precocious puberty, or as a manifestation of Pallister‑Hall syndrome. Neurofibrillary tangles are cytoplasmic aggregates of hyperphosphorylated tau that are best recognized in Alzheimer disease, other tau-associated neurodegenerative diseases, or as part of aging, but occasionally may be seen in low-grade neoplasms with a ganglion cell component as gangliocytoma or ganglioglioma. Herein, we report a case of hypothalamic hamartoma with neurofibrillary tangles.

Original languageEnglish (US)
Pages (from-to)480-484
Number of pages5
Issue number5
StatePublished - Oct 1 2016


  • gangliocytoma
  • ganglioglioma
  • hypothalamic hamartoma
  • neurofibrillary tangle
  • tau

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology


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