Hyperthyroidism and Thyrotoxicosis

Research output: Chapter in Book/Report/Conference proceedingChapter


Thyrotoxicosis is a term for excess thyroid hormone action. Hyperthyroidism is when thyroid is producing and releasing excess hormones. The most common cause is Graves’ hyperthyroidism, the next being toxic nodular goiter (Plummer’s disease). There are also several rare causes of overproduction of thyroid hormones. In conditions when destructive process in the thyroid results in release of stored hormones, the process is usually transient, and only symptomatic therapy is needed. For hyperthyroid overproduction category, either an 18-month course of antithyroid medication or ablative therapies such as surgery and radioactive iodine are needed. Long-term antithyroid therapy as an option for some patients with Graves’ disease has been recently recommended by ATA guidelines. Periodic TRAB (thyrotropin receptor antibodies) measurement during antithyroid therapy can be used as a guide for prediction of remission. Management of hyperthyroid and thyrotoxicosis syndromes should be tailored to the cause, associated with autoimmune manifestations, age of the patient, and other clinical considerations and patient preferences.

Original languageEnglish (US)
Title of host publicationEndocrinology and Diabetes
Subtitle of host publicationA Problem Oriented Approach: Second Edition
PublisherSpringer International Publishing
Number of pages11
ISBN (Electronic)9783030906849
ISBN (Print)9783030906832
StatePublished - Jan 1 2022


  • Antithyroid therapy
  • Graves’ disease
  • Hyperthyroidism
  • Radioactive iodine therapy
  • Thyroidectomy
  • Thyroiditis
  • Thyrotoxicosis
  • Thyrotropin receptor antibody (TRAB)

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Hyperthyroidism and Thyrotoxicosis'. Together they form a unique fingerprint.

Cite this