Hypertension during pregnancy is associated with coronary artery calcium independent of renal function

Andrea E. Cassidy-Bushrow, Lawrence F. Bielak, Andrew D. Rule, Patrick F. Sheedy, Stephen T. Turner, Vesna D. Garovic, Patricia A. Peyser

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: Hypertension during pregnancy (HDP) increases the risk of future coronary heart disease (CHD), but it is unknown whether this association is mediated by renal injury. Reduced renal function is both a complication of HDP and a risk factor for CHD. Methods: Logistic regression models were fit to examine the association between a history of HDP and the presence and extent of coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, in 498 women from the Epidemiology of Coronary Artery Calcification Study (mean age 63.3±9.3 years). Results: Fifty-two (10.4%) women reported a history of HDP. After adjusting for age at time of study participation, HDP was associated with increased serum creatinine later in life (p=0.014). HDP was positively associated with the presence of CAC after adjusting for age at time of study participation (OR=2.7, 95% CI 1.4-5.4). This association was slightly attenuated with adjustment for body size and blood pressure (OR=2.4, 95% CI 1.2-4.9) but was not further attenuated with adjustment for serum creatinine and urinary albumin/creatinine ratio (OR=2.6, 95% CI 1.3-5.3). Results were similar for CAC extent. Conclusions: HDP may increase a woman's risk of future CHD beyond traditional risk factors and renal function. Women with a history of HDP should be monitored for potential increased risk of CHD as they age.

Original languageEnglish (US)
Pages (from-to)1709-1716
Number of pages8
JournalJournal of Women's Health
Issue number10
StatePublished - Oct 1 2009

ASJC Scopus subject areas

  • Medicine(all)


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