Abstract
Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-nociceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (δ opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the δ opioid receptor is functional.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-14 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1997 |
Keywords
- Analgesic effect
- Human interleukin-2 (IL-2)
- Opioid receptor
- Pain threshold (PT)
- Signal transduction
- cAMP production
ASJC Scopus subject areas
- General Neuroscience
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