Human anti-mouse antibodies

George G. Klee

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Human anti-mouse antibodies (HAMA) are human immunoglobulins with specificity for mouse immunoglobulins. This topic currently is of interest because of the increased use of monoclonal mouse antibodies as diagnostic reagents both for in vitro laboratory measurements and for in vivo imaging studies. Monoclonal mouse antibodies also are being used therapeutically. This short article reviews the production of HAMA in patients receiving monoclonal antibodies and illustrates the potential ways that HAMA can interfere with immunoassay measurements. Methods for measuring and neutralizing HAMA also are discussed.

Original languageEnglish (US)
Pages (from-to)921-923
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number6
StatePublished - 2000

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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