HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans

S. Shastry, D. O. Toft, M. J. Joyner

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


In this study, we examined expression of heat shock proteins (HSP) 70 and 90 in human leucocytes after moderate-to-heavy exercise. We also compared baseline levels of HSP70 and HSP90 in trained (TR) and untrained (UT) subjects. Eleven TR subjects ran on a treadmill for 1 h at 70% of maximal oxygen consumption. The HSP levels were measured prior to exercise and 15 and 24 h after exercise. Baseline HSP levels were also measured in eight UT controls. Fifteen hours and 24 h after exercise, TR subjects showed no significant increases in HSP70 (P > 0.05). The HSP90 levels also did not change (P > 0.05). Baseline HSP70 levels in TR subjects were lower than in UT subjects (2.04 ± 0.51 ng vs. 4.52 ± 0.95 ng, P < 0.05), while HSP90 levels were similar in TR and UT subjects. We conclude that exercise at an intensity that is within normal limits for a moderately trained individual is not a sufficient stimulus of HSP70 production in leucocytes. We also conclude that blunted levels of baseline HSP70 expression in TR subjects might be a chronic adaptation to training.

Original languageEnglish (US)
Pages (from-to)139-146
Number of pages8
JournalActa Physiologica Scandinavica
Issue number2
StatePublished - 2002


  • Down-regulation
  • Maximal oxygen consumption
  • Molecular chaperones
  • Stress

ASJC Scopus subject areas

  • Physiology


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