TY - JOUR
T1 - How to use D-dimer in acute cardiovascular care
AU - Biomarker Study Group of the European Society of Cardiology (ESC) Acute Cardiovascular Care Association (ACCA)
AU - Giannitsis, Evangelos
AU - Mair, Johannes
AU - Christersson, Christina
AU - Siegbahn, Agneta
AU - Huber, Kurt
AU - Jaffe, Allan S.
AU - Peacock, W. Frank
AU - Plebani, Mario
AU - Thygesen, Kristian
AU - Möckel, Martin
AU - Mueller, Christian
AU - Lindahl, Bertil
PY - 2017/2/1
Y1 - 2017/2/1
N2 - D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation and subsequent degradation of cross-linked fibrin by plasmin. Many different assays for D-dimer testing are currently used in routine care. However, these tests are neither standardized nor harmonized. Consequently, only clinically validated assays and assay specific decision limits should be used for routine testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care.
AB - D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation and subsequent degradation of cross-linked fibrin by plasmin. Many different assays for D-dimer testing are currently used in routine care. However, these tests are neither standardized nor harmonized. Consequently, only clinically validated assays and assay specific decision limits should be used for routine testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care.
KW - D-dimer
KW - acute cardiovascular care
KW - pulmonary embolism
KW - thrombosis
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U2 - 10.1177/2048872615610870
DO - 10.1177/2048872615610870
M3 - Review article
C2 - 26450781
AN - SCOPUS:85050577559
SN - 2048-8726
VL - 6
SP - 69
EP - 80
JO - European heart journal. Acute cardiovascular care
JF - European heart journal. Acute cardiovascular care
IS - 1
ER -