@article{b1f73c30ef0742128f318a16c905c163,
title = "HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry",
abstract = "Primary sclerosing cholangitis (PSC) is strongly associated with several human leukocyte antigen (HLA) haplotypes. Due to extensive linkage disequilibrium and multiple polymorphic candidate genes in the HLA complex, identifying the alleles responsible for these associations has proven difficult. We aimed to evaluate whether studying populations of admixed or non-European descent could help in defining the causative HLA alleles. When assessing haplotypes carrying HLA-DRB1*13:01 (hypothesized to specifically increase the susceptibility to chronic cholangitis), we observed that every haplotype in the Scandinavian PSC population carried HLA-DQB1*06:03. In contrast, only 65% of HLA-DRB1*13:01 haplotypes in an admixed/non-European PSC population carried this allele, suggesting that further assessments of the PSC-associated haplotype HLA-DRB1*13:01-DQA1*01:03-DQB1*06:03 in admixed or multi-ethnic populations could aid in identifying the causative allele.",
keywords = "PSC, causative, human leukocyte antigen, multi-ethnic, trans-ancestry",
author = "{The UK-PSC Consortium} and Henriksen, {E. K.K.} and Viken, {M. K.} and M. Wittig and K. Holm and T. Folseraas and S. Mucha and E. Melum and Hov, {J. R.} and Lazaridis, {K. N.} and Juran, {B. D.} and O. Chazouill{\`e}res and M. F{\"a}rkkil{\"a} and Gotthardt, {D. N.} and P. Invernizzi and M. Carbone and Hirschfield, {G. M.} and Rushbrook, {S. M.} and E. Goode and Ponsioen, {C. Y.} and Weersma, {R. K.} and B. Eksteen and Yimam, {K. K.} and Gordon, {S. C.} and D. Goldberg and L. Yu and Bowlus, {C. L.} and A. Franke and Lie, {B. A.} and Karlsen, {T. H.}",
note = "Funding Information: We would like to thank the patients who participated in the study and all members of the International PSC Study Group (IPSCSG) contributing samples to the Immunochip study. The study received infrastructure support through the DFG Cluster of Excellence 306 {\textquoteleft}Inflammation at Interfaces{\textquoteright}, and received further support from the DFG RTG 1743 {\textquoteleft}Genes, Environment and Inflammation{\textquoteright} and the National Institutes of Health (NIH) grant RO1 DK84960. The study was funded by the Norwegian PSC Research Center and the European Union Seventh Framework Program (FP7/2007-2013, grant no. 262055). The authors have declared no conflicting interests. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2017",
month = oct,
doi = "10.1111/tan.13076",
language = "English (US)",
volume = "90",
pages = "228--233",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley-Blackwell",
number = "4",
}