Histomorphometric analysis of liver biopsies of treated patients with gaucher disease type 1

Rodrigo Tzovenos Starosta, Marina Siebert, Filippo Pinto E Vairo, Bruno Lafaiete de Lima Costa, Christiano Tomaso Ponzoni, Ida Vanessa Doederlein Schwartz, Carlos Thadeu Schmidt Cerski

Research output: Contribution to journalArticlepeer-review


Gaucher disease (GD) is an autosomal recessive lysosomal disorder caused by a disturbance in the metabolism of glucocerebroside in the macrophages. Most of its manifestations – hepatosplenomegaly, anemia, thrombocytopenia, and bone pain – are amenable to a macrophage-target therapy such as enzyme replacement. However, there is increasing evidence that abnormalities of the liver persist despite the specific GD treatment. In this work, we adapted histomorphometry techniques to the study of hepatocytes in GD using liver tissue of treated patients, developing the first morphometrical method for canalicular quantification in immunohistochemistry-stained liver biopsies, and exploring histomorphometric characteristics of GD. This is the first histomorphometric technique developed for canalicular analysis on histological liver biopsy samples.

Original languageEnglish (US)
Article numbere2021306
JournalAutopsy and Case Reports
StatePublished - 2021


  • Bile canaliculi
  • Biopsy, large-core needle
  • Gaucher disease
  • Hepatocytes
  • Image cytometry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Internal Medicine


Dive into the research topics of 'Histomorphometric analysis of liver biopsies of treated patients with gaucher disease type 1'. Together they form a unique fingerprint.

Cite this