High risk of postpartum relapses in neuromyelitis optica spectrum disorder

Eric C. Klawiter, Riley Bove, Liene Elsone, Enrique Alvarez, Nadja Borisow, Melissa Cortez, Farrah Mateen, Maureen A. Mealy, Jaime Sorum, Kerry Mutch, Sean M. Tobyne, Klemens Ruprecht, Guy Buckle, Michael Levy, Dean Wingerchuk, Friedemann Paul, Anne H. Cross, Anu Jacobs, Tanuja Chitnis, Brian Weinshenker

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Objective: To study the effect of pregnancy on the frequency of neuromyelitis optica spectrum disorder (NMOSD) relapse and evaluate rates of pregnancy-related complications in an international multicenter setting. Methods: We administered a standardized survey to 217 women with NMOSD from 7 medical centers and reviewed their medical records. We compared the annualized relapse rate (ARR) during a baseline period 2 years prior to a participant's first pregnancy to that during pregnancy and to the 9 months postpartum. We also assessed pregnancy-related complications. Results: There were 46 informative pregnancies following symptom onset in 31 women with NMOSD. Compared to baseline (0.17), ARR was increased both during pregnancy (0.44; p = 0.035) and during the postpartum period (0.69; p = 0.009). The highest ARR occurred during the first 3 months postpartum (ARR 1.33). A total of 8 of 76 (10.5%) with onset of NMOSD prior to age 40 experienced their initial symptom during the 3 months postpartum, 2.9 times higher than expected. Conclusions: The postpartum period is a particularly high-risk time for initial presentation of NMOSD. In contrast to published observations in multiple sclerosis, in neuromyelitis optica, relapse rate during pregnancy was also increased, although to a lesser extent than after delivery.

Original languageEnglish (US)
Pages (from-to)2238-2244
Number of pages7
Issue number22
StatePublished - 2017

ASJC Scopus subject areas

  • Clinical Neurology


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