Hepatobiliary Cancers

Krishan R. Jethwa, Christopher L. Hallemeier

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses the evaluation, management, role of radiotherapy, and the evolving role of particle therapy for patients with hepatobiliary cancers. Hepatobiliary cancers include hepatocellular carcinoma, gallbladder cancer, extrahepatic cholangiocarcinoma, and intrahepatic cholangiocarcinoma. The preferred treatment for patients with localized hepatobiliary cancers is surgical resection; however, the minority of patients are suitable for surgery due to the extent of disease at diagnosis or underlying comorbidities, including baseline liver dysfunction. There are a few series reporting results of proton therapy for patients with liver metastasis which demonstrate the early feasibility, safety, and efficacy of this strategy. Mild-to-moderate skin and chest-wall toxicity may be more common in patients receiving particle therapy when compared to patients receiving photon-based radiotherapy techniques, particularly for thinner patients with peripherally located tumors. Severe kidney injury is uncommon after radiotherapy for hepatobiliary cancers.

Original languageEnglish (US)
Title of host publicationPrinciples and Practice of Particle Therapy
Number of pages45
ISBN (Electronic)9781119707530
ISBN (Print)9781119707516
StatePublished - Jan 1 2022


  • extrahepatic cholangiocarcinoma
  • gallbladder cancer
  • hepatocellular carcinoma
  • intrahepatic cholangiocarcinoma
  • liver metastasis
  • particle therapy

ASJC Scopus subject areas

  • General Medicine


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