Hepatic Angiosarcoma: A Multi-institutional, International Experience with 44 Cases

Gregory C. Wilson, Nuria Lluis, Michael A. Nalesnik, Aziza Nassar, Teresa Serrano, Emilio Ramos, Michael Torbenson, Horacio J. Asbun, David A. Geller

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Hepatic angiosarcoma is a rare primary liver tumor. The aim of this current study was to evaluate the presentation and treatment outcomes in a modern cohort. Methods: This was a retrospective, multi-institutional, observational study of patients with histopathologic diagnoses of primary hepatic angiosarcoma from four institutions. Clinicopathologic characteristics, treatments, and patient outcomes were examined. Results: Forty-four patients with hepatic angiosarcoma were identified. Patients were predominantly Caucasian and presented at a median age of 63.7 years; 81.4% of patients had bilobar disease and 37.2% had metastatic disease at the time of presentation. Only 10 patients underwent surgical resection. Median overall survival for the entire cohort was 5.8 months (interquartile range 1.9–16.4), and 1-, 3-, and 5-year actual survival was 30.0%, 8.1%, and 5.6%, respectively. There were only two 5-year survivors, both of whom presented with localized disease and underwent curative resection. Conclusion: The prognosis for hepatic angiosarcoma remains quite poor. Surgical resection for localized disease results in the best outcomes. Unfortunately, current imaging modalities are often non- diagnostic, and most patients are unresectable at the time of presentation.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalAnnals of surgical oncology
Issue number2
StatePublished - Feb 15 2019

ASJC Scopus subject areas

  • Surgery
  • Oncology


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