Helicobacter pylori seropositivity as a risk factor for pancreatic cancer

Rachael Z. Stolzenberg-Solomon, Martin J. Blaser, Paul J. Limburg, Guillermo Perez-Perez, Philip R. Taylor, Jarmo Virtamo, Demetrius Albanes

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Background: Pancreatic cancer is among the most fatal cancers worldwide and one for which few preventable risk factors have been established. Gastric carriage of Helicobacter pylori, particularly cytotoxin-associated gene-A-positive (CagA+) strains, is known to be a risk factor for peptic ulcer disease and gastric cancer and may have a similar etiologic relationship with pancreatic cancer. Methods: We investigated the association of H. pylori carriage and exocrine pancreatic cancer in a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29 133 male Finnish smokers aged 50-69 years at baseline. Case subjects (n = 121) were matched on date of baseline serum collection, study center, age, trial intervention, and completion of the dietary questionnaire to 226 control subjects who were alive at the time the matching case subject was diagnosed and who remained free of cancer, during up to 10 years of follow-up. Levels of immunoglobulin G antibodies to H. pylori whole-cell and CagA+ antigens from stored baseline serum were measured by enzyme-linked immunosorbent assay. Smoking-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by use of conditional logistic regression. Statistical tests were two-sided. Results: Seroprevalence of H. pylori was 82% and 73% among case and control subjects, respectively. Compared with seronegative subjects, those with H. pylori or CagA+ strains were at statistically significantly elevated risk of pancreatic cancer (OR = 1.87 [95% CI = 1.05 to 3.34]; OR = 2.01 [95% CI = 1.09 to 3.70], respectively). Conclusions: Our findings support a possible role for H. pylori carriage in the development of exocrine pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalJournal of the National Cancer Institute
Issue number12
StatePublished - Jun 20 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Helicobacter pylori seropositivity as a risk factor for pancreatic cancer'. Together they form a unique fingerprint.

Cite this