Heart failure with preserved ejection fraction diagnosis and treatment: An updated review of the evidence

Marco Giuseppe Del Buono, Giulia Iannaccone, Roberto Scacciavillani, Salvatore Carbone, Massimiliano Camilli, Giampaolo Niccoli, Barry A. Borlaug, Carl J. Lavie, Ross Arena, Filippo Crea, Antonio Abbate

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Over the last several decades, clinicians and clinical scientists have had growing interest in heart failure (HF) diagnosis and treatment. While HF with reduced ejection fraction (EF) is a well-known clinical entity with several therapeutic strategies proven to be successful, HF with preserved ejection fraction is a more heterogenous syndrome with a prevalence that has increased in the last two decades, without effective therapeutic strategies. Great strides have been made in the detection of predisposing risk factors and pathological mechanisms; however, pharmacological therapies have shown to be ineffective in reducing cardiovascular mortality in the HF with preserved EF (HFpEF) population, opening the way to the necessity of developing new precision medicine based approaches. On the other hand, novel therapies and device interventions still require refinements with the ultimate goal of offering new clinically treatments for the HFpEF population. The aim of the present review is to provide insights into the HFpEF pathophysiology, diagnostic pathways and the latest updates on treatment strategies and their potential future application in routine clinical practice.

Original languageEnglish (US)
Pages (from-to)570-584
Number of pages15
JournalProgress in Cardiovascular Diseases
Issue number5
StatePublished - Sep 1 2020


  • Diagnosis
  • HFpEF
  • Heart failure
  • Pharmacological
  • Therapeutics
  • Treatment

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Heart failure with preserved ejection fraction diagnosis and treatment: An updated review of the evidence'. Together they form a unique fingerprint.

Cite this