TY - JOUR
T1 - Heart failure after myocardial infarction
T2 - A review
AU - Hellermann, Jens P.
AU - Jacobsen, Steven J.
AU - Gersh, Bernard J.
AU - Rodeheffer, Richard J.
AU - Reeder, Guy S.
AU - Roger, Véronique L.
N1 - Funding Information:
This study was supported in part by grants from the Public Health Service, Washington, D.C.; the National Institutes of Health (AR30582 and RO1 HL 59205), Bethesda, Maryland; and from a Northland Postdoctoral Fellowship Award from the American Heart Association, Dallas, Texas.
PY - 2002/8
Y1 - 2002/8
N2 - PURPOSE: The effects of survival after myocardial infarction on the prevalence of chronic heart failure have not been well characterized. We reviewed studies of the incidence, mortality, and predictors of heart failure after myocardial infarction, and suggest directions for further research. METHODS AND RESULTS: We conducted a review of the literature from 1978 to 2000. Of 33 identified articles, 18 (55%) included heart failure as a primary endpoint. The mean in-hospital incidence of heart failure after myocardial infarction differed significantly by study design; it was highest in population-based studies and lowest in clinical trials (37% vs. 18%, P <0.01). Only 10 studies reported the incidence of subsequent heart failure. One-year mortality ranged from 16% to 39% and showed no improvement with time. Patients with in-hospital heart failure after myocardial infarction had a two- to sixfold greater in-hospital mortality and up to a fivefold increased 1-year mortality compared with patients without heart failure. The most consistent risk factors for the development of heart failure after myocardial infarction were advanced age, female sex, diabetes, and an increased heart rate at the time of admission. CONCLUSION: The reported incidence of, and mortality from, heart failure after myocardial infarction varies by study design. Additional research on the etiology and prognosis of late heart failure after myocardial infarction is needed.
AB - PURPOSE: The effects of survival after myocardial infarction on the prevalence of chronic heart failure have not been well characterized. We reviewed studies of the incidence, mortality, and predictors of heart failure after myocardial infarction, and suggest directions for further research. METHODS AND RESULTS: We conducted a review of the literature from 1978 to 2000. Of 33 identified articles, 18 (55%) included heart failure as a primary endpoint. The mean in-hospital incidence of heart failure after myocardial infarction differed significantly by study design; it was highest in population-based studies and lowest in clinical trials (37% vs. 18%, P <0.01). Only 10 studies reported the incidence of subsequent heart failure. One-year mortality ranged from 16% to 39% and showed no improvement with time. Patients with in-hospital heart failure after myocardial infarction had a two- to sixfold greater in-hospital mortality and up to a fivefold increased 1-year mortality compared with patients without heart failure. The most consistent risk factors for the development of heart failure after myocardial infarction were advanced age, female sex, diabetes, and an increased heart rate at the time of admission. CONCLUSION: The reported incidence of, and mortality from, heart failure after myocardial infarction varies by study design. Additional research on the etiology and prognosis of late heart failure after myocardial infarction is needed.
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U2 - 10.1016/S0002-9343(02)01185-3
DO - 10.1016/S0002-9343(02)01185-3
M3 - Review article
C2 - 12361819
AN - SCOPUS:0036701646
SN - 0002-9343
VL - 113
SP - 324
EP - 330
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 4
ER -