Health-related quality of life in kidney donors from the last five decades: Results from the RELIVE study

C. R. Gross, E. E. Messersmith, B. A. Hong, S. G. Jowsey, C. Jacobs, B. W. Gillespie, S. J. Taler, A. J. Matas, A. Leichtman, R. M. Merion, H. N. Ibrahim

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Live donation benefits recipients, but the long-term consequences for donors remain uncertain. Renal and Lung Living Donors Evaluation Study surveyed kidney donors (N = 2455; 61% women; mean age 58, aged 24-94; mean time from donation 17 years, range 5-48 years) using the Short Form-36 Health Survey (SF-36). The 95% confidence intervals for White and African-American donors included or exceeded SF-36 norms. Over 80% of donors reported average or above average health for their age and sex (p < 0.0001). Donors' age-sex adjusted physical component summary (PCS) scores declined by half a point each decade after donation (p = 0.0027); there was no decline in mental component summary (MCS) scores. White donors' PCS scores were three points higher (p = 0.0004) than non-Whites'; this difference remained constant over time. Nine percent of donors had impaired health (PCS or MCS score >1 SD below norm). Obesity, history of psychiatric difficulties and non-White race were risk factors for impaired physical health; history of psychiatric difficulties was a risk factor for impaired mental health. Education, older donation age and a first-degree relation to the recipient were protective factors. One percent reported that donation affected their health very negatively. Enhanced predonation evaluation and counseling may be warranted, along with ongoing monitoring for overweight donors.

Original languageEnglish (US)
Pages (from-to)2924-2934
Number of pages11
JournalAmerican Journal of Transplantation
Issue number11
StatePublished - Nov 2013


  • Kidney
  • kidney donor
  • living donor
  • organ donation
  • quality of life

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)


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