Hb Cambridge-MA [β144(HC1)-β146(HC3)Lys-Tyr-His→0 (HBB c.433 A>T)]: A new high oxygen affinity variant

Jennifer L. Oliveira, Kenneth Swanson, Patricia Wendt, Thomas D. Caughey, James D. Hoyer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A new β hemoglobin (Hb) variant, Hb Cambridge-MA [β144(HC1) β146(HC3)Lys-Tyr-His→0 (AAG>TAG) (HGVS: HBB c.433 A>T] is described. The variant was characterized by high performance liquid chromatography (HPLC), alkaline, acid, globin chain and capillary electrophoresis, isoelectric focusing (IEF), heat and isopropanol stability, p50 analyses, intact globin mass spectrometry (MS) and DNA sequencing. The new variant shows high oxygen (O2) affinity and is associated with mild polycythemia.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
Issue number6
StatePublished - Dec 2010


  • Cambridge
  • Congenital
  • Erythrocytosis
  • Hemoglobin (Hb) variant
  • Hemoglobinopathy
  • High oxygen (O ) affinity
  • Left-shifted dissociation curve
  • Polycythemia
  • p50

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical


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