Guideline-Driven Management of Hypertension: An Evidence-Based Update

Robert M. Carey, Jackson T. Wright, Sandra J. Taler, Paul K. Whelton

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Several important findings bearing on the prevention, detection, and management of hypertension have been reported since publication of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline. This review summarizes and places in context the results of relevant observational studies, randomized clinical trials, and meta-analyses published between January 2018 and March 2021. Topics covered include blood pressure measurement, patient evaluation for secondary hypertension, cardiovascular disease risk assessment and blood pressure threshold for drug therapy, lifestyle and pharmacological management, treatment target blood pressure goal, management of hypertension in older adults, diabetes, chronic kidney disease, resistant hypertension, and optimization of care using patient, provider, and health system approaches. Presenting new information in each of these areas has the potential to increase hypertension awareness, treatment, and control which remain essential for the prevention of cardiovascular disease and mortality in the future.

Original languageEnglish (US)
Pages (from-to)827-846
Number of pages20
JournalCirculation research
Issue number7
StatePublished - Apr 2 2021


  • American Heart Association
  • antihypertensive agents
  • blood pressure
  • cardiovascular disease
  • hypertension
  • mortality

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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