Glycemic control in non-critically ill hospitalized patients: A systematic review and meta-analysis

Mohammad Hassan Murad, John A. Coburn, Fernando Coto-Yglesias, Svitlana Dzyubak, Ahmad Hazem, Melanie A. Lane, Larry J. Prokop, Victor M. Montori

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


Background: The effect of intensive therapy to achieve tight glycemic control in patients hospitalized in non-critical care settings is unclear. Methods:Weconducted a systematic review and meta-analysis to determine the effect of intensive glycemic control strategies on the outcomes of death, stroke, myocardial infarction, incidence of infection, and hypoglycemia. We included randomized and observational studies. Bibliographic databases were searched through February 2010. Random effects model was used to pool results across studies. Results: Nineteen studies (nine randomized and 10 observational studies) were included. The risk of bias across studies was moderate. Meta-analysis demonstrates that intensive glycemic control was not associated with significant effect on the risk of death, myocardial infarction, or stroke. There was a trend for increased risk of hypoglycemia (relative risk, 1.58; 95% confidence interval,0.97-2.57), particularly in surgical studies and when the planned glycemic target was achieved. Intensive glycemic control was associated with decreased risk of infection (relative risk, 0.41; 95% confidence interval, 0.21-0.77) that was mainly derived from studies in surgical settings. Conclusion: Intensive control of hyperglycemia in patients hospitalized in non-critical care settings may reduce the risk of infection. The quality of evidence is low and mainly driven by studies in surgical settings.

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


Dive into the research topics of 'Glycemic control in non-critically ill hospitalized patients: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this