Glial cell inclusions and the pathogenesis of neurodegenerative diseases

David W. Miller, Mark R. Cookson, Dennis W. Dickson

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


In this review, we discuss examples that show how glial-cell pathology is increasingly recognized in several neurodegenerative diseases. We also discuss the more provocative idea that some of the disorders that are currently considered to be neurode-generative diseases might, in fact, be due to primary abnormalities in glia. Although the mechanism of glial pathology (i.e. modulating glutamate excitotoxicity) might be better established for amyotrophic lateral sclerosis (ALS), a role for neuronal-glial interactions in the pathogenesis of most neurodegenerative diseases is plausible. This burgeoning area of neuroscience will receive much attention in the future and it is expected that further understanding of basic neuronal-glial interactions will have a significant impact on the understanding of the fundamental nature of human neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalNeuron Glia Biology
Issue number1
StatePublished - 2004


  • Protein aggregation
  • SOD1
  • a-synuclein
  • tau

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


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