Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Hanna K. Sanoff; Lindsay A. Renfro; Pradeep Poonnen; Pratibha Ambadwar; Daniel J. Sargent; Richard M. Goldberg; Howard McLeod

doi:10.1371/journal.pone.0094727

Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Hanna K. Sanoff, Lindsay A. Renfro, Pradeep Poonnen, Pratibha Ambadwar, Daniel J. Sargent, Richard M. Goldberg, Howard McLeod

Quantitative Health Sciences

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3 Scopus citations

Abstract

Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.

Original language	English (US)
Article number	e94727
Journal	PloS one
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0094727
State	Published - Apr 11 2014

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title = "Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer",

abstract = "Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.",

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T1 - Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

AU - Sanoff, Hanna K.

AU - Renfro, Lindsay A.

AU - Poonnen, Pradeep

AU - Ambadwar, Pratibha

AU - Sargent, Daniel J.

AU - Goldberg, Richard M.

AU - McLeod, Howard

PY - 2014/4/11

Y1 - 2014/4/11

N2 - Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.

AB - Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC.

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Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Abstract

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