@article{be99d3f0b03448b19ec219bf7b6a774c,
title = "Germline miRNA DNA variants and the risk of colorectal cancer by subtype",
abstract = "MicroRNAs (miRNAs) regulate up to one-third of all protein-coding genes including genes relevant to cancer. Variants within miRNAs have been reported to be associated with prognosis, survival, response to chemotherapy across cancer types, in vitro parameters of cell growth, and altered risks for development of cancer. Five miRNA variants have been reported to be associated with risk for development of colorectal cancer (CRC). In this study, we evaluated germline genetic variation in 1,123 miRNAs in 899 individuals with CRCs categorized by clinical subtypes and in 204 controls. The role of common miRNA variation in CRC was investigated using single variant and miRNA-level association tests. Twenty-nine miRNAs and 30 variants exhibited some marginal association with CRC in at least one subtype of CRC. Previously reported associations were not confirmed (n = 4) or could not be evaluated (n = 1). The variants noted for the CRCs with deficient mismatch repair showed little overlap with the variants noted for CRCs with proficient mismatch repair, consistent with our evolving understanding of the distinct biology underlying these two groups.",
author = "Lindor, {Noralane M.} and Larson, {Melissa C.} and DeRycke, {Melissa S.} and McDonnell, {Shannon K.} and Saurabh Baheti and Fogarty, {Zachary C.} and Win, {Aung Ko} and Potter, {John D.} and Buchanan, {Daniel D.} and Mark Clendenning and Newcomb, {Polly A.} and Graham Casey and Steven Gallinger and {Le Marchand}, Lo{\"i}c and Hopper, {John L.} and Jenkins, {Mark A.} and Goode, {Ellen L.} and Thibodeau, {Stephen N.}",
note = "Funding Information: Study samples were from the Colon Cancer Family Registry (Colon CFR), described in detail elsewhere (Newcomb et al.,) and at http://coloncfr.org. Between 1997 and 2012, the Colon CFR recruited families via both population-based probands, recently diagnosed CRC cases from state or regional cancer registries in Australia, the USA, and Canada as well as clinic-based probands enrolled from multiple-case families referred to family-cancer clinics in the same countries. Samples in this study were collected from the Australasian Colorectal Cancer Family Registry (Melbourne, Victoria, Australia), Hawaii Family Registry of Colon Cancer (Honolulu, HI), Mayo Colorectal Family Registry (Rochester, MN), Ontario Familial Colorectal Cancer Registry (Toronto, Ontario, Canada), Seattle Familial Colorectal Cancer Registry (Seattle, WA), and University of Southern California Consortium (Los Angeles, CA). Mismatch repair (MMR) status for all tumors was established, as previously described (Ait Ouakrim et al.,). All participants provided informed consent. Protocols were approved by the Institutional Review Board at each site. Study samples were from the Colon Cancer Family Registry (Colon CFR), described in detail elsewhere (Newcomb et al.,) and at http://coloncfr.org. Between 1997 and 2012, the Colon CFR recruited families via both population-based probands, recently diagnosed CRC cases from state or regional cancer registries in Australia, the USA, and Canada as well as clinic-based probands enrolled from multiple-case families referred to family-cancer clinics in the same countries. Samples in this study were collected from the Australasian Colorectal Cancer Family Registry (Melbourne, Victoria, Australia), Hawaii Family Registry of Colon Cancer (Honolulu, HI), Mayo Colorectal Family Registry (Rochester, MN), Ontario Familial Colorectal Cancer Registry (Toronto, Ontario, Canada), Seattle Familial Colorectal Cancer Registry (Seattle, WA), and University of Southern California Consortium (Los Angeles, CA). Publisher Copyright: {\textcopyright} 2016 The Authors Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.",
year = "2017",
month = mar,
day = "1",
doi = "10.1002/gcc.22420",
language = "English (US)",
volume = "56",
pages = "177--184",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "3",
}