Genomics basics: DNA structure, gene expression, cloning, genetic mapping, and molecular tests

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Genomics is the study of the structure and function of the human genome including genes and their surrounding DNA sequences. The over 3 billion base pairs of the human genome have now been sequenced and approximately 25 000 genes acknowledged. However, only 1% of the entire genome has been assigned to protein coding and decades more work is anticipated to define the functional relevance of noncoding DNA as well as the basis and consequences of sequence variations among individuals. For medical scientists, the focus remains on discovering both disease-causing and disease-susceptibility genes. For pharmaceutical companies, the opportunity to develop molecularly targeted therapy is not going unnoticed. For the practicing physician, the prospect of genomic medicine that incorporates molecular diagnosis and pathogenesis-targeted therapy requires basic understanding of terminology and concepts in molecular biology and the corresponding laboratory tests.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalSeminars in Cardiothoracic and Vascular Anesthesia
Issue number4
StatePublished - Dec 2006


  • DNA
  • Genes
  • Genomics
  • Sequence variation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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