Abstract
Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 441-451 |
| Number of pages | 11 |
| Journal | Journal of Cutaneous Pathology |
| Volume | 42 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2015 |
Keywords
- angiomyofibroblastoma
- angiomyxoma
- cellular angiofibroma
- genital stromal tumors
- smooth muscle tumors
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology