Genetically Determined Procoagulant States and Heparin Use

Robert D. McBane

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The propensity for both arterial and venous thrombotic disorders involves a genetic predetermination that operates in concert with environmental factors or triggers. Appropriate clinical assessment and therapeutic recommendations for patients with thrombosis requires a thorough knowledge of genetic variables that influence this propensity. This review focuses on the pathophysiology, natural history, and molecular biology of defined thrombophilic risk factors relevant to the care of patients with thrombotic disorders.

Original languageEnglish (US)
Pages (from-to)427-442
Number of pages16
JournalSeminars in Cardiothoracic and Vascular Anesthesia
Issue number4
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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