Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry

Xuejuan Jiang, J. Esteban Castelao, David Vandenberg, Angel Carracedo, Carmen M. Redondo, David V. Conti, Jesus P. Paredes Cotoré, John D. Potter, Polly A. Newcomb, Michael N. Passarelli, Mark A. Jenkins, John L. Hopper, Steven Gallinger, Loic Le Marchand, María E. Martínez, Dennis J. Ahnen, John A. Baron, Noralane M. Lindor, Robert W. Haile, Manuela Gago-Dominguez

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Recent genome-wide studies identified a risk locus for colorectal cancer at 18q21, which maps to the SMAD7 gene. Our objective was to confirm the association between SMAD7 SNPs and colorectal cancer risk in the multi-center Colon Cancer Family Registry. Materials and Methods: 23 tagging SNPs in the SMAD7 gene were genotyped among 1,592 population-based and 253 clinic-based families. The SNP-colorectal cancer associations were assessed in multivariable conditional logistic regression. Results: Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer. These associations were similar among the population- and the clinic-based families, though they were significant only among the former. Marginally significant differences in the SNP-colorectal cancer associations were observed by use of nonsteroidal anti-inflammatory drugs, cigarette smoking, body mass index, and history of polyps. Conclusions: SMAD7 SNPs were associated with colorectal cancer risk in the Colon Cancer Family Registry. There was evidence suggesting that the association between rs12953717 and colorectal cancer risk may be modified by factors such as smoking and use of nonsteroidal anti-inflammatory drugs.

Original languageEnglish (US)
Article numbere60464
JournalPloS one
Issue number4
StatePublished - Apr 3 2013

ASJC Scopus subject areas

  • General


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