Genetic and environmental contributions

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


There is a remarkable variability in insulin action in humans. Depending upon the definition of the insulin resistance syndrome, different inheritability/environmental influences on insulin action are reported. The environmental contributions to insulin resistance appear to account for ~50% of this syndrome. Obese and sedentary insulin-resistant individuals can see dramatic improvement in insulin sensitivity with weight reduction and fitness training. The degree to which obesity is determined by genetic influences will have a substantial impact on insulin resistance in the Western populations. Familial components also appear to account for ~50% of the variation and insulin action (as commonly defined by glucose metabolic effects).

Original languageEnglish (US)
Pages (from-to)S22-S24
JournalNutrition Reviews
Issue number3 II
StatePublished - Mar 1 2000

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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