Gender influences health-related Quality of Life in IPF

Mei Lan K. Han, Jeffrey Swigris, Lyrica Liu, Brian Bartholmai, Susan Murray, Nicholas Giardino, Bruce Thompson, Margaret Frederick, Daner Li, Marvin Schwarz, Andrew Limper, Kevin Flaherty, Fernando J. Martinez

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist. Methods: Data were drawn from the NIH-sponsored Lung Tissue Research Consortium (LTRC). Demographic and pulmonary physiology data along with MMRC, SF-12, and SGRQ scores from women vs. men were compared with two-sample t-tests. Multivariate linear regression was used to examine the association between SF-12 component scores and gender while adjusting for other relevant variables. Results: The study sample consisted of 147 men and 74 women. Among several baseline variables, only DLCO% predicted differed between women and men, (43.7 vs. 38.0, p = 0.03). In general, men exhibited lower (better) MMRC scores (1.7 vs. 2.4, p = 0.02), particularly those with milder disease as measured by DLCO% predicted. In an adjusted analysis, SF-12 PCS scores in men were lower (worse) than women (p = 0.01), an effect that was more pronounced in men with greater dyspnea scores. In a similar analysis, SF-12 MCS scores in women were lower than men (worse) (48.3 vs. 54.4, p = 0.0004), an effect that was more pronounced in women with greater dyspnea scores. Conclusions: Significant gender differences in HRQL exist in IPF. As compared to women, men reported less severe dyspnea, had worse SF-12 PCS scores, but better SF-12 MCS scores. Dyspnea appears to have a greater impact on the physical HRQL of men and the emotional HRQL of women. An improved understanding of the mechanism behind these differences is needed to better target interventions.

Original languageEnglish (US)
Pages (from-to)724-730
Number of pages7
JournalRespiratory Medicine
Issue number5
StatePublished - May 2010


  • Gender
  • Health-related Quality of Life
  • Interstitial pulmonary fibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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