Gastrointestinal basidiobolomycosis: Morphologic findings in a cluster of six cases

Omar M. Yousef, Jerry D. Smilack, David M. Kerr, Robert Ramsey, Louis Rosati, Thomas V. Colby

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


We describe the histopathologic features of 6 cases of gastrointestinal basidiobolomycosis examined at 4 Phoenix, AZ, area hospitals during the last 4 years. Resected stomach and intestinal specimens were characterized by marked mural thickening with fibrosis, prominent tissue eosinophil infiltration and palisading granulomatous inflammation around pate fungal hyphae. In 2 cases, there was colonic perforation. Basidiobolus ranarum hyphae (associated with spore-like spherules in 4 cases) were identified within tissue sections; the irregularly branched, thin-walled, occasionally septated hyphae were typically surrounded by a thick eosinophilic cuff (Splendore-Hoeppli phenomenon). Although the histologic features of B ranarum are well described in the skin and subcutaneous tissue, gastrointestinal involvement has presented considerable diagnostic difficulty. Before the occurrence of this cluster of cases, intra-abdominal B ranarum infection has been reported only rarely.

Original languageEnglish (US)
Pages (from-to)610-616
Number of pages7
JournalAmerican journal of clinical pathology
Issue number5
StatePublished - 1999


  • Basidiobolus
  • Eosinophils
  • Gastrointestinal
  • Granuloma
  • Hyalohyphomycosis
  • Mycosis
  • Splendore- Hoeppli
  • Zygomycosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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