TY - JOUR
T1 - Gaps in nutritional research among older adults with cancer
AU - Presley, Carolyn J.
AU - Dotan, Efrat
AU - Soto-Perez-de-Celis, Enrique
AU - Jatoi, Aminah
AU - Mohile, Supriya G.
AU - Won, Elizabeth
AU - Alibhai, Shabbir
AU - Kilari, Deepak
AU - Harrison, Robert
AU - Klepin, Heidi D.
AU - Wildes, Tanya M.
AU - Mustian, Karen
AU - Demark-Wahnefried, Wendy
N1 - Funding Information:
This work was funded by the National Institute on Aging (grant no. U13 AG038151). The work was also funded by the American Cancer Society and a Patient-Centered Outcomes Research Institute (PCORI) program contract ( 4634 ). The work received support from the James Wilmot Cancer Institute (WCI), the Alliance for Clinical Trials in Oncology (National Cancer Institute of the National Institutes of Health under award numbers U10CA18082 and 1UG1CA189823 ), and the National Cancer Institute (UG1 CA189961). This work was made possible by the generous donors to the WCI geriatric oncology philanthropy fund. All statements in this report, including its findings and conclusions, are solely those of the authors, do not necessarily represent the official views of the funding agencies, and do not necessarily represent the views of the Patient-Centered Outcomes Research Institute (PCORI), its Board of Governors or Methodology Committee.
Funding Information:
Supriya Mohile serves as a consultant for Seattle Genetics. Tanya Wildes has received funding through the 1K12CA167540 and UL1 TR000448 grants. Carolyn Presley has received funding from the Celgene IIT grant. The authors report no other disclosures.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research.
AB - Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research.
KW - Cancer
KW - Geriatrics
KW - Nutrition
KW - Older adults
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U2 - 10.1016/j.jgo.2016.04.006
DO - 10.1016/j.jgo.2016.04.006
M3 - Review article
C2 - 27197919
AN - SCOPUS:84971324913
SN - 1879-4068
VL - 7
SP - 281
EP - 292
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 4
ER -