Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)

V. Vajs, S. Vugdelija, S. Trifunović, I. Karadžić, N. Juranić, S. Macura, S. Milosavljević

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3- pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
Issue number5
StatePublished - Jul 2003


  • Antimicrobial activity
  • Deoxyfurohyperforin A
  • Hypericum perforatum

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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