From Slowly Progressive Amnesic Syndrome to Rapidly Progressive Alzheimer Disease

R. J. Caselli, M. E. Couce, D. Osborne, H. G. Deen, J. P. Parisi

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


A 57-year-old woman had a neuropsychologically documented 5-year history of a slowly progressive amnesic syndrome followed by a 1-year history of rapidly progressive dementia. There was no family history of dementia. Magnetic resonance imaging failed to show a structural basis, electroencephalography failed to show changes of Creutzfeldt-Jakob disease, and cerebrospinal fluid examination was normal. A diagnosis of Alzheimer disease was confirmed by brain biopsy. The abrupt change in disease course was unique but suggested probable overlap between posited subtypes of Alzheimer disease.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalAlzheimer disease and associated disorders
Issue number3
StatePublished - 1998


  • Alzheimer disease-
  • Amnesic syndrome-
  • Rapidly progressive dementia

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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