Fracture risk in patients with ankylosing spondylitis: A population based study

C. Cooper, L. Carbone, C. J. Michet, E. J. Atkinson, W. M. O'Fallon, L. J. Melton

Research output: Contribution to journalArticlepeer-review

214 Scopus citations


Objective: To assess the risk of fractures among patients with ankylosing spondylitis (AS). Methods: A population based cohort study compared fracture incidence in an inception cohort of 158 Rochester, Minnesota residents newly diagnosed with AS between 1935 and 1989 with expected rates from the same community. Results: In 2,398 person-years of observation, there was no increase in the risk of limb fractures, but there was a pronounced Increase in the risk of thoracolumbar compression fractures (standardized morbidity ratio = 7.6; 95% CI, 4.3-12.6) among those with AS. Conclusion: These data point to the importance of measures aimed at maintaining axial skeletal status in patients with AS.

Original languageEnglish (US)
Pages (from-to)1877-1882
Number of pages6
JournalJournal of Rheumatology
Issue number10
StatePublished - 1994


  • Ankylosing spondylitis
  • Fracture
  • Osteoporosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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