Fatty acid metabolism in adaptive immunity

Xian Zhou, Xingxing Zhu, Hu Zeng

Research output: Contribution to journalReview articlepeer-review


Fatty acids (FAs) not only are a key component of cellular membrane structure, but also have diverse functions in biological processes. Recent years have seen great advances in understanding of how FA metabolism contributes to adaptive immune response. Here, we review three key processes, FA biosynthesis, FA oxidation and FA uptake, and how they direct T and B cell functions during immune challenges. Then, we will focus on the relationship between microbiota derived FAs, short-chain FAs, and adaptive immunity. Along the way, we will also discuss the outstanding controversies and challenges in the field.

Original languageEnglish (US)
Pages (from-to)584-599
Number of pages16
JournalFEBS Journal
Issue number3
StatePublished - Feb 2023


  • B cells
  • T cells
  • Treg
  • fatty acid
  • germinal centre
  • memory
  • mitochondrial
  • oxidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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