Maria Eugenia Guicciardi, Gregory J. Gores

Research output: Chapter in Book/Report/Conference proceedingChapter


Fas (CD95, APO-1) belongs to the death receptor family, a subgroup of the tumor necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily. These cell surface cytokine receptors are able to initiate an apoptotic signaling cascade after binding a group of structurally related ligands or specific antibodies [1]. The members of this family are type-I transmembrane proteins with a C-terminal intracellular tail, a membrane spanning region, and an extracellular N-terminal domain. Through interaction with the N-terminal domain, the receptors bind their cognate ligands (called death ligands), the majority of which are type-II transmembrane proteins belonging to the TNF family of proteins and comprised of an intracellular N-terminal domain, a transmembrane region, and a C-terminal extracellular tail. The signature features of the death receptors are represented by a highly homologous region in their extracellular domains containing one to five cysteine-rich domains (CRD) and a ∼80-amino acid cytoplasmic sequence known as death domain (DD), which is required to initiate the death signal.

Original languageEnglish (US)
Title of host publicationSignaling Pathways in Liver Diseases
PublisherSpringer Berlin Heidelberg
Number of pages10
ISBN (Print)9783642001499
StatePublished - 2010

ASJC Scopus subject areas

  • General Medicine


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