Familial Amyotrophic Lateral Sclerosis

Kevin Boylan

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


Genes linked to amyotrophic lateral sclerosis (ALS) susceptibility are being identified at an increasing rate owing to advances in molecular genetic technology. Genetic mechanisms in ALS pathogenesis seem to exert major effects in about 10% of patients, but genetic factors at some level may be important components of disease risk in most patients with ALS. Identification of gene variants associated with ALS has informed concepts of the pathogenesis of ALS, aided the identification of therapeutic targets, facilitated research to develop new ALS biomarkers, and supported the establishment of clinical diagnostic tests for ALS-linked genes.

Original languageEnglish (US)
Pages (from-to)807-830
Number of pages24
JournalNeurologic clinics
Issue number4
StatePublished - Nov 2015


  • ALS
  • Amyotrophic lateral sclerosis
  • Familial ALS
  • Genetic testing
  • Genetics
  • Phenotypes

ASJC Scopus subject areas

  • Clinical Neurology


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